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This could theoretically lead to reduced appetite and cravings (2). There are actually a whole bunch of studies in rats showing that Garcinia Cambogia consistently leads to significant weight loss (3, 4, 5, 6). However, what works in rats doesnt always work in humans. Bottom Line: Studies in rats show that the active ingredient in Garcinia Cambogia can inhibit a fat producing enzyme called Citrate Lyase and increase serotonin levels, leading to significant weight loss.